Gitelman's Syondrome: a Hereditary Disorder Characterized by Hypokalemia and Hypomagnesaemia
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چکیده
منابع مشابه
Gitelman’s Syndrome: A Hereditary Disorder Characterized by Hypokalemia and Hypomagnesaemia
Gitelman’s syndrome is a type of hereditary tubular disorder, which is caused by inactive mutations in the gene, which encodes thiazide sensitive sodium chloride cotransporter (SLC12A3) in the distal convoluted tubule. Biochemical characteristic is comparable to effect of thiazide diuretics: hypokalemia, hypomagnesaemia, hypocalciuria, hypokalemic alkalosis and blood pressure is normal or lower...
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A new, autosomally inherited abnormal fibrinogen associated with hypofibrinogenemia has been described in several members of a family. Plasma fibrinogen measured either as thrombin-clottable protein or by immunodiffusion revealed a fibrinogen level ranging between 60 and 90 mg/100 ml. The thrombin time of plasma or purified fibrinogen was prolonged and only partially corrected by the addition o...
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متن کاملA new tubular disorder with hypokalaemic metabolic alkalosis, severe hypermagnesuric hypomagnesaemia, hypercalciuria and cardiomyopathy.
Renal tubular magnesium loss in association with a defect in tubular chloride reabsorption has been reported in Bartter’s and Gitelman’s syndromes. Clinically, both syndromes are characterized by hypokalaemic metabolic alkalosis, renal salt wasting, hyperreninaemic hyperaldosteronism and altered renal prostaglandin metabolism [1]. In Bartter’s syndrome, hypomagnesaemia occurs in 20% of patients...
متن کاملA Case of Severe Hypomagnesaemia
Hypomagnesaemia is a common finding that occurs in hospitalised patients and can be caused by renal or extrarenal wasting. Because it is not routinely tested, even severe hypomagnesaemia can be missed. In cases of extrarenal wasting, the kidney can decrease its magnesium excretion to very low levels. A systematic diagnostic approach allows the proper diagnosis and treatment of hypomagnesaemia. ...
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ژورنال
عنوان ژورنال: Electronic Journal of General Medicine
سال: 2009
ISSN: 2516-3507
DOI: 10.29333/ejgm/82653